How many IVF cycles are too many? The question of when to stop doing IVF and move on to donor eggs or adoption is a source of debate among both fertility patients and practitioners. Each cycle takes a toll on finances, energy, relationships, careers, and emotions. A common question is when to call it quits. We now have new information that can help guide our decision. The Journal of the American Medical Association recently published a study showing that 66%of women going through IVF will have a child by the 6th cycle. As expected, the best predictor of success was maternal age, and the best outcomes were for women under the age of 40. One of the most notable observations, however, was that live birth rates continue to increase up to the ninth cycle attempt. With over 257,000 IVF cycles included in this study, this is the strongest evidence to date to encourage resolve and tenacity in the face of IVF failure. While most people understand that unlimited cycles are unrealistic, at least we now have some scientific guidance on what is a reasonable long term plan.